Uncov­er­ing the Spa­tial Reg­u­la­tion of γδ T Cells: Toward Recep­tor-Guid­ed Immunotherapy

Gam­ma delta (γδ) T cells are a unique type of immune cell that can help the body detect and destroy can­cer. How­ev­er, their exact role in sol­id tumors has remained unclear, part­ly because tra­di­tion­al lab­o­ra­to­ry mod­els do not ful­ly reflect how these cells behave in the human body 1. In this talk, I will present a com­pre­hen­sive strat­e­gy to study γδ T cells direct­ly in patients with col­orec­tal can­cer, using matched sam­ples from blood, healthy colon tis­sue, pri­ma­ry tumors, and liv­er metas­tases as well as nov­el engi­neer­ing tech­niques by using advan­tage of γδ T cell recep­tors and opti­mal co-stim­u­la­tion2.

1 Beringer, D.X., Straete­mans, T., Minguet, S., Riil­lo, C., Lynch, L., Sebestyen, Z., and Kuball, J. (2025) Dis­rupt­ing the bal­ance between acti­vat­ing and inhibito­ry recep­tors of gam­madeltaT cells for effec­tive can­cer immunother­a­py. Nat Rev Can­cer. 25, 590 – 612

2 Her­nan­dez-Lopez, P., Riil­lo, C., Gasull-Celades, L., Lom­men, J.G.E., Hei­jhu­urs, S., Zheng, J., van Bruggen, S., Zintchenko, M., Bran­dl, S.M., Minguet, S., Kuball, J., and Beringer, D.X. (2026) Cis- and trans-bind­ing chimeric cos­tim­u­la­to­ry recep­tors enhance T‑cell fit­ness and tumor con­trol. Cell Mol Immunol. 23, 79 – 93

Gam­ma delta (γδ) T cells are a unique type of immune cell that can help the body detect and destroy can­cer. How­ev­er, their exact role in sol­id tumors has remained unclear, part­ly because tra­di­tion­al lab­o­ra­to­ry mod­els do not ful­ly reflect how these cells behave in the human body 1. In this talk, I will present a com­pre­hen­sive strat­e­gy to study γδ T cells direct­ly in patients with col­orec­tal can­cer, using matched sam­ples from blood, healthy colon tis­sue, pri­ma­ry tumors, and liv­er metas­tases as well as nov­el engi­neer­ing tech­niques by using advan­tage of γδ T cell recep­tors and opti­mal co-stim­u­la­tion2.

1 Beringer, D.X., Straete­mans, T., Minguet, S., Riil­lo, C., Lynch, L., Sebestyen, Z., and Kuball, J. (2025) Dis­rupt­ing the bal­ance between acti­vat­ing and inhibito­ry recep­tors of gam­madeltaT cells for effec­tive can­cer immunother­a­py. Nat Rev Can­cer. 25, 590 – 612

2 Her­nan­dez-Lopez, P., Riil­lo, C., Gasull-Celades, L., Lom­men, J.G.E., Hei­jhu­urs, S., Zheng, J., van Bruggen, S., Zintchenko, M., Bran­dl, S.M., Minguet, S., Kuball, J., and Beringer, D.X. (2026) Cis- and trans-bind­ing chimeric cos­tim­u­la­to­ry recep­tors enhance T‑cell fit­ness and tumor con­trol. Cell Mol Immunol. 23, 79 – 93

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Uncovering the Spatial Regulation of γδ T Cells: Toward Receptor-Guided Immunotherapy
Uncovering the Spatial Regulation of γδ T Cells: Toward Receptor-Guided Immunotherapy
Uncovering the Spatial Regulation of γδ T Cells: Toward Receptor-Guided Immunotherapy

Jür­gen Kuball

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Jürgen Kuball | Uncovering the Spatial Regulation of γδ T Cells: Toward Receptor-Guided Immunotherapy
Jür­gen Kuball, Uni­ver­si­ty Med­ical Cen­ter Utrecht, THE NETHERLANDS

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