Aurélie Poli

Aller­goOn­col­o­gy: Lessons Learned from the Aller­gy-Glioblas­toma Connection

Abstract

This pre­sen­ta­tion delves into the fas­ci­nat­ing inter­sec­tion of aller­gy and oncol­o­gy, with a par­tic­u­lar focus on glioblas­toma. We will define the field of Aller­goOn­col­o­gy, describ­ing the cur­rent inter­face between aller­gol­o­gy and oncol­o­gy and dis­cussing var­i­ous path­ways involved in the asso­ci­a­tion between aller­gy and glioblastoma.

We will delve into our recent work demon­strat­ing the pro­tec­tive role of aller­gic air­way inflam­ma­tion against glioblas­toma pro­gres­sion in a murine mod­el, and its impli­ca­tions on sys­temic and local immu­ni­ty. Inves­ti­gat­ing how aller­gic inflam­ma­tion delays glioblas­toma pro­gres­sion in mice reveals intri­cate immune mech­a­nisms, includ­ing the tran­scrip­tion­al repro­gram­ming of microglia and the poten­ti­a­tion of local and adap­tive sys­temic immu­ni­ty (Doi: 10.1111/all.15545) .

Addi­tion­al­ly, we will dis­cuss our col­lab­o­ra­tive efforts between the Euro­pean Acad­e­my of Aller­gy and Clin­i­cal Immunol­o­gy (EAACI) and the Euro­pean Asso­ci­a­tion of Neu­ro-Oncol­o­gy (EANO), aim­ing to refine the clas­si­fi­ca­tion of aller­gic dis­eases and gliomas for enhanced research in Aller­goOn­col­o­gy (Doi: 10.1111/all.15994).

Through these dis­cus­sions, we aim to pro­vide a com­pre­hen­sive under­stand­ing of the Aller­goOn­col­o­gy nexus, empha­siz­ing the impor­tance of pre­clin­i­cal mod­els, bio­mark­er research, and col­lab­o­ra­tive efforts in advanc­ing our knowl­edge and improv­ing patient out­comes in this intrigu­ing field.

Biography/​Link

https://​orcid​.org/​0​000 – 0002-7986 – 0761