Christoph Klose

Neu­ro-immune inter­ac­tions at bar­ri­er surfaces

Abstract

The ner­vous and immune sys­tems, as pri­ma­ry sen­so­ry units, con­tin­u­ous­ly mon­i­tor tis­sue integri­ty and respond to dis­tur­bances. Recent research has uncov­ered sig­nal­ing path­ways through which the ner­vous sys­tem reg­u­lates ILCs and type 2 immune respons­es, involv­ing neu­ropep­tides and neu­ro­trans­mit­ters. ILCs, pre­dom­i­nant­ly found at mucos­al bar­ri­ers, play cru­cial roles in immune respons­es, yet their neu­ronal con­trol remains poor­ly understood. 

To inves­ti­gate this inter­ac­tion sys­tem­at­i­cal­ly, we’ve devel­oped advanced genet­ic tools enabling exper­i­men­tal manip­u­la­tion. By inte­grat­ing cut­ting-edge tech­nolo­gies in immunol­o­gy, neu­ro­science, and genomics, our goal is to elu­ci­date neu­ro-immune inter­ac­tions and iden­ti­fy poten­tial ther­a­peu­tic targets.

Biography/​Link

Christoph Klose earned his Ph.D. in Mol­e­c­u­lar Med­i­cine from Albert-Lud­wigs-Uni­ver­si­ty, Freiburg, in 2007. Fol­low­ing post-doc­tor­al train­ing at Weill Cor­nell Med­i­cine, New York City, he estab­lished an inde­pen­dent research group at the Depart­ment of Immunol­o­gy, Charite — Uni­ver­si­tatsmedi­zin Berlin. His research sig­nif­i­cant­ly advanced our under­stand­ing of innate lym­phoid cells (ILCs) by demon­strat­ing their par­al­lels with T cells and iden­ti­fy­ing key reg­u­la­tors of type 2 immune responses. 

His cur­rent focus is on dis­sect­ing ILC func­tions and explor­ing inter­ac­tions between the immune and ner­vous sys­tems. Dr. Klose received the Robert-Koch post-doc­tor­al immunol­o­gy award in 2015 and has been rec­og­nized as a high­ly cit­ed researcher since 2020. Fund­ing for his work comes from an ERC grant and the Emmy-Noe­ther pro­gram of the Ger­man Research Foundation.

http://​charite​-mikro​bi​olo​gie​.de/​k​l​o​s​e​-​l​a​b​o​r​a​t​o​ry/