Domini­ka Nowis

The use of mRNA-based immunother­a­pies in exper­i­men­tal oncology

Abstract

With effec­tive and man­u­fac­tured at unprece­dent­ed speed anti-COVID19 vac­cines as well as Katal­in Kariko and Drew Weiss­man 2023 award­ed Nobel Prize in Phys­i­ol­o­gy or Med­i­cine, mRNA ther­a­peu­tics have tak­en pre­ven­tive med­i­cine by storm. In oth­er areas, how­ev­er, no such an impres­sive progress can be assigned to mRNA-based drugs. In my talk I will present the cur­rent sta­tus of mRNA-based immunother­a­peu­tic approach­es being eval­u­at­ed in oncol­o­gy and dis­cus the poten­tial rea­sons for their so far sub­op­ti­mal performance.

Biography/​Link

Pro­fes­sor Domini­ka Nowis, M.D., Ph.D. is head of the Lab­o­ra­to­ry of Exper­i­men­tal Med­i­cine (LEM), Fac­ul­ty of Med­i­cine, Med­ical Uni­ver­si­ty of War­saw. Prof. Nowis gained her research expe­ri­ence at Depart­ment of Immunol­o­gy, Med­ical Uni­ver­si­ty of War­saw, Dana-Far­ber Can­cer Insti­tute, Boston, USA, MRC Weather­all Insti­tute of Mol­e­c­u­lar Med­i­cine, Oxford Uni­ver­si­ty, Oxford, UK, Uni­ver­si­ty Col­lege Dublin, Ire­land, Indi­ana Uni­ver­si­ty School of Med­i­cine, USA and Uni­ver­si­ty of Verona, Italy.

She is an author or co-author of over 90 pub­li­ca­tions pub­lished in inter­na­tion­al­ly rec­og­nized sci­en­tif­ic jour­nals such as Nature Comm, PLoS Med­i­cine, Am J Pathol, Blood, Haema­to­log­i­ca, Onco­gene, Can­cer Res, CA: Can­cer Jour­nal for Clin­i­cians, Clin Can­cer Res, JACS, Nucle­ic Acid Research. Her pub­li­ca­tions have been cit­ed over 7,000 times, her H‑index equals 33. She is an author (in 4^rd-8^th edi­tions) and sci­en­tif­ic co-edi­tor (8^th edi­tion) of “Immunol­o­gy” aca­d­e­m­ic text­book (in polish).

Prof. Nowis con­sid­ers the dis­cov­ery of the car­diotox­ic effects of the pro­tea­some inhibitors and statin-depen­dent decreased glu­cose uptake by can­cer cells and cells involved in car­bo­hy­drates home­osta­sis her major sci­en­tif­ic achieve­ments so far. For the past few years she has been work­ing on the devel­op­ment of research tech­niques to study anti­tu­mor immune respons­es and final­ly set­tled in the field of oncoim­munol­o­gy and mRNA-based therapies.

LEM web­page: https://​lmd​.wum​.edu​.pl/

Orcid ID: 0000 – 0003-2748 – 9523

https://​www​.acad​e​mia​-net​.org/​p​r​o​f​i​l​e​/​d​o​m​i​n​i​k​a​-​n​o​w​i​s​/​7​8​850