Aurélie Poli
AllergoOncology: Lessons Learned from the Allergy-Glioblastoma Connection
Abstract
This presentation delves into the fascinating intersection of allergy and oncology, with a particular focus on glioblastoma. We will define the field of AllergoOncology, describing the current interface between allergology and oncology and discussing various pathways involved in the association between allergy and glioblastoma.
We will delve into our recent work demonstrating the protective role of allergic airway inflammation against glioblastoma progression in a murine model, and its implications on systemic and local immunity. Investigating how allergic inflammation delays glioblastoma progression in mice reveals intricate immune mechanisms, including the transcriptional reprogramming of microglia and the potentiation of local and adaptive systemic immunity (Doi: 10.1111/all.15545) .
Additionally, we will discuss our collaborative efforts between the European Academy of Allergy and Clinical Immunology (EAACI) and the European Association of Neuro-Oncology (EANO), aiming to refine the classification of allergic diseases and gliomas for enhanced research in AllergoOncology (Doi: 10.1111/all.15994).
Through these discussions, we aim to provide a comprehensive understanding of the AllergoOncology nexus, emphasizing the importance of preclinical models, biomarker research, and collaborative efforts in advancing our knowledge and improving patient outcomes in this intriguing field.