The Role of ILC2 in Tis­sue Home­osta­sis and Neoplasia

ILC2 are tis­sue-res­i­dent immune cells that play an impor­tant role in reg­u­lat­ing type‑2 inflam­ma­tion. Beyond dri­ving inflam­ma­to­ry respons­es, ILC2 are also emerg­ing as reg­u­la­tors of tis­sue and immune home­osta­sis. We have shown that ILC2 direct­ly inter­act with reg­u­la­to­ry T cells to con­strain the mag­ni­tude of the adap­tive type‑2 immune response. More­over, we found ILC2 as impor­tant tis­sue-res­i­dent immune cells in the healthy pan­creas, where they can inter­act with spe­cif­ic fibrob­last sub­sets; by exert­ing both pos­i­tive and neg­a­tive selec­tive pres­sures, ILC2 can orches­trate fibrob­last home­osta­sis in healthy, inflamed and can­cer conditions.